Skip to main content
. Author manuscript; available in PMC: 2019 Oct 12.
Published in final edited form as: J Mol Biol. 2018 Jul 12;430(20):3631–3641. doi: 10.1016/j.jmb.2018.07.007

Figure 2.

Figure 2

The csg operons encode the curli-specific genes [52]. CsgA is the major curlin subunit and is secreted into the periplasmic space in an unstructured conformation via SecYEG [3]. CsgA is maintained as unstructured in the periplasmic space by the amyloid inhibitor, CsgC [13]. Soluble CsgA is secreted to the outer membrane via the nonameric CsgG pore and nonameric CsgE adaptor complex [58,59,63]. CsgA assumes a β-sheet rich conformation upon interaction with the minor curlin subunit and nucleator protein, CsgB, which is tethered to CsgG via CsgF [11,56,60,62].