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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: Free Radic Biol Med. 2018 May 22;127:108–115. doi: 10.1016/j.freeradbiomed.2018.05.077

Table 1.

Genetic variants in human GPX1 associated with diabetes/obesity-related phenotypes

Analyzed variant(dbSNP) Other designation Metabolic phenotype Reference
rs1050450 594C/T, Pro198Leu The CT/TT genotype had higher waist-hip ratios, triacylglycerol concentrations, homeostasis model assessment for β-cell function, and systolic and diastolic blood pressures in men [115]
The CT/TT genotype had higher body fat mass, insulin and HOMA-IR in women [115]
Leu carriers had higher lipoperoxides and MDA in LDL [118]
Leu carriers showed higher DNA damage after Se supplementation [114]
Leu carriers had higher lipoperoxides and MDA in LDL, lower GPX activity [113]
Erythrocyte GPX activity was lowered with the T allele dose [113]
Pro198Leu The variant T allele was associated with a higher risk of developing diabetic peripheral neuropathy [116]
Ala5/Ala6+ Pro198Leu Ala6/198Leu polymorphism had a 40% decrease in GPX1 activity [85]
-602A/G+2C/T 25% decrease in transcriptional activity [85]
Pro200Leu linked to morbid obesity in central Mexican women [117]
rs8179169 Arg5Pro Had an effect on erythrocyte Se, with lower concentrations in individuals with the GC genotype [132]
rs3448 XT/CC The CT/TT allele was associated with higher plasma concentrations of isoprostane and advanced oxidation protein products [21]

GPX1, glutathione peroxidase 1; HOMA-IR, homeostasis model assessment of insulin resistance; LDL, Low-density lipoprotein; MDA, malondialdehyde; Se, selenium.