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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Cancer Res. 2018 Aug 15;78(19):5600–5617. doi: 10.1158/0008-5472.CAN-18-0562

Figure 5. NRP2 in macrophages affects tumor growth.

Figure 5.

(A) Schematic diagram for subcutaneous tumor progression model. 2×106 or 500,000 UNKC-6141 cells were subcutaneously implanted into NRP2fl/flCSF1R-iCre mice. Tumor progression was monitored for the indicated time periods. (B) Graph showing relative tumor volume for control and test tumors (2×106 cells implanted). (C) Scatter plot representation of the final volume of the harvested tumors (2×106 cells implanted). (D,F) Immunoblot analysis showing efficient knock out of NRP2 from macrophages for experiment B and E. (E, G) Graphical representation of final volume of harvested tumors (n=3 or 5, 500,000 cells implanted). (H) RT-PCR showing efficient knock out of NRP2 from CD11b+ myeloid cells isolated from test tumors for G.