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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Cancer Res. 2018 Aug 15;78(19):5600–5617. doi: 10.1158/0008-5472.CAN-18-0562

Figure 7. Transcriptome analysis from CD11b+ myeloid cells by next generation RNA-Seq.

Figure 7.

(A) Schematic diagram showing experimental design. (B) Representative canonical pathways from Ingenuity Pathway Analysis are shown with gene counts and -log(p-value). (C) Representative functional annotation clusters from DAVID database are shown. (D) Representative list of genes related to macrophage polarization whose expressions were significantly altered in the CD11b+ myeloid population, following NRP2 deletion in macrophages in test tumors. (E) RT-PCR analysis in separate biological replicates (pooled, n=3 in either control or test) showing altered expression of genes in CD11b+ cells following NRP2 deletion in macrophages in test tumors.