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. 2018 Oct 2;8:14600. doi: 10.1038/s41598-018-32712-8

Figure 2.

Figure 2

Incubation times, PrPSc levels and neurodegeneration in Lag3 WT and KO mice after prion infection. (A) Survival curves of Lag3 WT and KO mice after prion infection. Median incubation time: 173.5 days for Lag3 WT mice and 171 days for Lag3 KO mice. Twenty mice containing both genders were pooled together for both of the Lag3 WT and KO mice. Log-rank (Mantel-Cox) test was used for the comparison of survival curves. (B) Representative image of a western blot examining PK-resistant PrPSc levels in the brains of Lag3 WT and KO mice. Full-length blots are presented in Supplementary Fig. 4. (C) Representative images of NeuN staining in the hippocampus of the Lag3 WT and Lag3 KO mice. Scale bars: 100 μm for the upper images and 50 μm for the lower images. (D) Quantitative data of the NeuN positive areas shown in (C). *P < 0.05 (n = 6). n.s, not significant. NBH, Normal Brain Homogenate; RML6, Rocky Mountain Laboratory, Passage 6.