Fig. 4.

Architecture of the BCL10-MALT1 interface. a, b Top and side view of one repeat of the BCL10-MALT1 holo-complex as visible in the cryo-EM density. Position of BCL10-MALT1 interface BM-I is indicated in (b). c Close up view of the BCL10 and MALT1 interaction site I (BM-I) shown as ribbon model in blue and orange, respectively. The interacting residues are shown in stick representation. Mutations introduced are colored magenta. d HEK293 cells were co-transfected with tagged MALT1B and BCL10 wt and mutant constructs as indicated. Co-IP was carried out using anti-Flag antibodies and analyzed by WB for co-precipitation