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. 2018 Oct 2;8:14652. doi: 10.1038/s41598-018-32376-4

Figure 2.

Figure 2

Simvastatin inhibited apoptosis in rat myocardial tissue in LPS induced inflammation by down-regulating cleaved caspase 3 expression. Representative images with quantitative analysis of apoptotic cardiomyocytes that were challenged with LPS for induction of inflammation and either pretreated with simvastatin 20 and simvastatin 40 before LPS. The expression of cleaved caspase 3 in rat myocardial tissue examined by immunohistochemical staining, magnification 200x. (a) Control group. (b) Intense cytoplasmic staining of cleaved caspase 3 in cardiomyocytes in LPS group, as characteristic of cell in apoptosis. Marked reduction of apoptotic cardiomyocytes in the simvastatin 20 (c) and simvastatin 40 (d) groups.