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. 2017 Dec 29;37(10):1293–1307. doi: 10.1038/s41388-017-0055-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. If you remix, transform, or build upon this article or a part thereof, you must distribute your contributions under the same license as the original. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/.

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Fig. 7 — miR-451 expression is disrupted in human B lymphoma cells with hyper Myc activity. a qRT-PCR analyzing the level of miR-451 in Myc highly-expressed and Myc-low-expressed human lymphoma cell lines with human CD20 positive bone marrow lymphocytes as control. The Y-axis shows the relative amount of miR-451. Representative study from three different experiments is shown. b Immunohistochemical staining of representative specimens from human diffuse large B cell lymphomas (DLBCL) patients showing the high Myc and low Myc protein levels. Inflammatory reactive lymph nodes with undetectable level of Myc as negative control (Myc-). Insets (400×) represent tissues in red squares. c Immunohistochemical staining of CD20 showing the identity of B cell lineage. d q-RT-PCR analyzing miR-451 levels in human DLBCL samples with high and low Myc protein levels. RNA from reactive lymph nodes with undetectable Myc used as control. The Y-axis shows the relative amount of miR-451. q-RT-PCR was repeated twice. e q-RT-PCR analyzing miR-451 levels in subcutaneously transplanted human lymphoma P493 cells with a Myc-inducible system. The Y-axis shows the relative levels of miR-451. f Model for the interaction of miR-451-Myc: decrease of miR-451 expression derepresses Myc in B-lymphocytes and high Myc level inversely inhibits miR-451 transcription. This positive feedback loop sustains the Myc level above the threshold that contributes to B-lymphomagenesis. (*) p < 0.05 (t-test), (**) p < 0.01 (t-test)