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. 2018 Oct 2;8:14671. doi: 10.1038/s41598-018-33025-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Raman spectra of the border zone myocardium obtained from 5 patients. (a) A representative HE-stained image of the boundary between the infarcted region (dashed area A) and non-infarcted region (dashed area B) of the heart tissue excised from patient 3. Scale bar represents 1 mm. Representative Raman spectra of non-infarcted myocardium (b) and infarcted myocardium (c) of each patient. Each spectrum was averaged to obtain sufficient signal-to-noise ratio for the detail identification of Raman bands, and normalized by the integrated intensity of each Raman spectrum.