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. 2018 Oct 2;8:14605. doi: 10.1038/s41598-018-33038-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Annotation of differentially expressed circRNAs. (A)Most significantly enriched GO (−log10 (P value)) terms of miRNAs gene symbols according to biological process, marked red; cellular component, marked yellow; molecular function, marked blue. (B) KEGG pathway enrichment analysis of up and down regulated miRNAs. (C) Prediction of interaction networks between differentially expressed miRNAs and circRNAs. (D) Annotation of miRNA targets, KEGG pathway enrichment analysis of the mRNA targets of dysregulated miRNAs.