Table 1.

Insolubilizing residue-residue interactions, defined by $ℳ<0$ and the strict significance criteria requiring both $|ℳ|$ and $\mathcal{V}$ values to be higher than 95% of the equivalent quantities computed from randomly shuffled datasets (Sig$ℳ$ and Sig$\mathcal{V}\ge 0.95$).

Interactions	Residue pairs	$\mathbf{ℳ}$	Sig$\mathbf{ℳ}$	$\mathcal{V}$	Sig$\mathcal{V}$
π-π	TRP-TRP	−0.412	0.99	0.181	0.99
	TRP-PHE	−0.207	1	0.052	1
	TYR-TRP	−0.177	1	0.038	0.99
	TYR-PHE	−0.124	0.97	0.019	0.99
His-π	HIS-TYR	−0.155	1	0.038	0.99
	HIS-TRP	−0.191	0.99	0.063	1
	HIS-PHE	−0.122	0.96	0.022	0.95
Cation-π	ARG-TRP	−0.238	1	0.074	1
	ARG-PHE	−0.120	0.99	0.017	0.99
	ARG-TYR	−0.101	0.98	0.017	0.98
	LYS -TRP	−0.162	0.97	0.068	0.98
Amino-π	GLN-TRP	−0.359	1	0.135	1
	GLN-PHE	−0.128	1	0.028	1
	ASN-PHE	−0.140	1	0.024	0.99
	ASN-TRP	−0.183	1	0.044	0.98
	GLN-TYR	−0.141	0.99	0.024	0.95
Anion-π	ASP-TRP	−0.211	1	0.049	1
Aromatic-containing	TRP-SER	−0.294	1	0.104	1
	PHE-CYS	−0.232	1	0.062	1
	TRP-ALA	−0.206	1	0.048	1
	TRP-PRO	−0.205	1	0.045	1
	TYR-SER	−0.129	1	0.021	1
	TRP-LEU	−0.192	1	0.037	1
	TRP-GLY	−0.153	0.99	0.033	0.98
	TRP-CYS	−0.267	0.99	0.076	0.97
	TYR-GLY	−0.109	0.98	0.021	0.97
	TRP-ILE	−0.114	0.97	0.024	0.98
His-containing	HIS-ALA	−0.108	1	0.016	0.98
	HIS-PRO	−0.124	0.99	0.021	0.97
	HIS-LEU	−0.110	0.97	0.027	0.99
Arg-containing	ARG-SER	−0.152	1	0.025	1
	ARG-ARG	−0.184	0.99	0.036	0.99
	ARG-PRO	−0.128	0.99	0.030	0.99
	ARG-LEU	−0.084	0.99	0.008	0.96
	ARG-CYS	−0.230	0.98	0.062	0.98
	ARG-GLN	−0.166	1	0.033	1
	ARG-ASN	−0.120	0.99	0.023	1
Asn/Gln-containing	ASN-GLN	−0.158	0.99	0.032	0.99
	GLN-CYS	−0.152	0.95	0.051	1
Miscellaneous	LEU-CYS	−0.195	1	0.050	1
	LEU-SER	−0.074	0.97	0.010	0.97
	SER-SER	−0.109	0.96	0.019	0.95