Table 2.

Solubilizing residue-residue interactions, defined by $ℳ>0$ and the strict significance criteria requiring both $|ℳ|$ and $\mathcal{V}$ values to be higher than 95% of the equivalent quantities computed from randomly shuffled datasets (Sig$ℳ$ and Sig$\mathcal{V}\ge 0.95$).

Interactions	Residue pairs	$\mathbf{ℳ}$	Sig$\mathbf{ℳ}$	$\mathcal{V}$	Sig$\mathcal{V}$
Lys-salt bridges	LYS-GLU	0.115	1	0.017	1
	LYS-ASP	0.105	0.97	0.013	0.96
Aliphatic-aliphatic	VAL-VAL	0.156	1	0.025	1
	ILE-ILE	0.125	1	0.018	1
	VAL-ILE	0.096	1	0.010	1
	GLY-VAL	0.114	1	0.015	1
	ILE-ALA	0.072	1	0.006	0.97
	LEU-ILE	0.064	0.99	0.007	1
	LEU-VAL	0.058	0.99	0.004	0.96
	GLY-GLY	0.113	0.98	0.014	0.96
Aliphatic-containing	ILE-LYS	0.134	1	0.026	1
	VAL-GLU	0.120	1	0.017	1
	VAL-THR	0.086	1	0.010	0.99
	GLY-ASP	0.114	1	0.017	0.99
	ILE-THR	0.080	1	0.008	0.97
	GLY-THR	0.093	0.99	0.015	0.99
	GLY-GLU	0.105	0.99	0.012	0.96
	ILE-GLU	0.089	0.99	0.011	0.95
	ALA-LYS	0.095	0.98	0.013	0.97
	VAL-PRO	0.068	0.95	0.008	0.98
	VAL-LYS	0.097	0.95	0.014	0.98
Miscellaneous	GLU-THR	0.153	1	0.032	1