Fig. 6.

Structure of CTX-M-14 β-lactamase determined by MHz SFX. a 2Fo-Fc map at 1 sigma overlaid on Fo-Fc map at 3 sigma around covalently bound avibactam from molecular replacement using a solvent-free version of the 5TWD β-lactamase structure from ref. ¹⁸ as the starting model. b Representation of covalently bound avibactam to OG of Ser70, stabilized by hydrogen bonds and hydrophobic interactions with surrounding amino acids of CTX-M-14. Figure was prepared using Ligplot⁵³