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. 2018 Oct 2;8:14668. doi: 10.1038/s41598-018-32859-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Nestin is a pan-EC enriched protein in the human adult. RNA-seq data from 176 individual samples from 37 different human tissues were used to generate Spearman pair wise correlation values between NES transcript expression and transcripts for all other mapped protein coding genes. Gene ontology (GO) analysis was performed on the 150 transcripts that were most highly correlated with NES: (A) the 10 most significant GO functional groupings and (B) a summary of GO functional groupings with removal of redundant terms (plot produced using REVIGO [http://revigo.irb.hr/] before modification). (C) Correlation plots showing the relationship between NES and the EC-enriched transcripts CLEC14A, ROBO4, TIE1, SOX17, TEK, ESAM, NRP1 and CD34. Correlation values and corresponding p-values are shown in the top left and bottom right of each scatter plot, respectively. Human tissue sections from (D) cerebral cortex, adrenal gland, thyroid, skeletal muscle, lung, tonsil, spleen, gallbladder, pancreas, salivary gland, esophagus, stomach, duodenum, colon, urinary bladder, adipose, placenta, ovary, testis, prostate and (E) heart, kidney and breast were stained for protein encoded by NES. See also Supplemental Fig. 1 and Supplemental Tables 1 and 2.