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. 2018 Oct 2;8:14668. doi: 10.1038/s41598-018-32859-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Nestin expression is not restricted to proliferating EC. RNA-seq data from 176 individual samples from 37 different human tissues were used to generate Spearman pair wise correlation values between NES transcript values and those encoding for the known proliferation markers (A) proliferating cell nuclear antigen (PCNA) (B) marker of proliferation Ki-67 (MKI67) and (C) cyclin-dependent kinase 2 (CDK2). Correlation values and corresponding p-values are shown in the top left and bottom right of each scatter plot, respectively. (D) Human tissue sections from the bone marrow, placenta, esophagus, lung and cerebral cortex were stained for protein encoded by NES, PCNA, MKI67, and CDK2. See also Supplemental Fig. 1 and Supplemental Table 1.