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. 2018 Oct 2;8:14638. doi: 10.1038/s41598-018-33020-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Differentially expressed genes in mouse model of MI derived by RNA-seq. (A) An unsupervised cluster analysis of the mRNA-seq data of MI and sham at 3 different stages. (B) Volcano plot showing DEGs in 1 day, 1 week, and 8 weeks post-MI. (C) An unsupervised cluster analysis of the miR-seq data of MI. (D) Volcano plot showing DEmiRs in MI. Red dots indicate significantly upregulated miRNAs and blue dots indicate downregulated miRNAs.