Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Oct 2;8:14659. doi: 10.1038/s41598-018-32613-w

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

BCAAem treatment leads to amelioration of vessel architecture in muscles of mdx mice. Probe-based confocal laser endomicroscopy was performed in TAs of BCAAem-treated and untreated male and female mdx mice. Treated and untreated mdx mice were injected with CD31 Alexa-Fluor 488 and α-SMA Alexa-Fluor 647 (n = 5 per group) (a) and with CD31 Alexa-Fluor 488 and VE-cadherin Alexa-Fluor 647 (n = 5 per group) (b). Representative images show increased α-SMA+ pericyte vessel coverage and aligned VE-cad+ cells organized in regular wall structures. Scale bar, 200 µm. Quantification of the number of CD31+ vessels and α-SMA+ and VE-cad+ cells per field of view of the muscles of BCAAem-treated and untreated male and female mice is shown. (c) All data are presented as the mean ± s.e.m. Statistical error analysis was performed by two-way ANOVA with Bonferroni correction; *p < 0.05, ****p < 0.0001 indicate comparisons that reflect significant differences relative to the untreated group.