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. 2018 Sep 26;9:1084. doi: 10.3389/fphar.2018.01084

FIGURE 5.

FIGURE 5

(A) Effects of intraperitoneal administration (i.p.) of vehicle (open circles), 1.0 mg/kg (gray diamonds), 3.0 mg/kg (black diamonds) or 10.0 mg/kg (open diamonds) AB-PINACA on rectal temperature (in°C) as a function of time. Points represent group means, ±SEM, and any points without error bars indicate that the variability is contained within the point. Inset – Lowest rectal temperatures recorded following injection of vehicle, 10.0 mg/kg AB-PINACA, or 10.0 mg/kg rimonabant administered 60 min before 10.0 mg/kg AB-PINACA. Bars represent group means, ±SEM, and asterisks represent significant differences from vehicle. The asterisk in the panel A inset indicates that the hypothermic effect produced by AB-PINACA is significantly different (P < 0.05) from that observed following injection of vehicle and from that observed following administration of rimonabant with AB-PINACA. (B) Effects of vehicle (open circles), 30.0 mg/kg (gray triangles) or 100.0 mg/kg (black triangles) 4OH-AB-PINACA on rectal temperature (in°C) as a function of time. All graph properties as described in Figure 1. Inset – Lowest rectal temperatures recorded following injection of vehicle, 100.0 mg/kg 4OH-AB-PINACA, or 10.0 mg/kg rimonabant administered 60 min before 100.0 mg/kg 4OH-AB-PINACA. All graph properties as described in Figure 1. The asterisk in the panel B inset indicates that the hypothermic effect produced by 4OH-AB-PINACA is significantly different (P < 0.05) from that observed following injection of vehicle and from that observed following administration of rimonabant with 4OH-AB-PINACA.