Table 2.
Affinity, potency and efficacy values (in vitro studies).
| [3H]CP-55,940 binding |
[35S]GTPγS binding |
cAMP accumulation |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Ligand | pKi | Ki (nM) | N | pEC50 | EC50 (nM) | EMAX | N | pIC50 | IC50 (nM) | IMAX | N |
| CP-55,940 | 9.07 ± 0.13a,† | 0.92† | 3 | 8.03 ± 0.18a | 11.0 | 64.0 ± 3.8a | 3 | 7.85 ± 0.16a,b,c | 16.3 | 86.7 ± 6.4a | 3 |
| 9Δ-THC | 8.10 ± 0.17a | 9.6 | 4 | 8.05 ± 0.14a | 12.5 | 39.0 ± 2.7b | 7 | 7.35 ± 0.20a,c | 68.8 | 91.1 ± 2.3a | 6 |
| AB-PINACA | 8.75 ± 0.25a | 4.0 | 7 | 8.06 ± 0.17a | 12.8 | 71.9 ± 5.8a | 10 | 8.65 ± 0.19b | 3.9 | 72.0 ± 2.1b | 6 |
| 4OH-AB-PINACA | 6.82 ± 0.09b | 159 | 3 | 6.09 ± 0.12b | 952 | 92.6 ± 13.4a | 5 | 6.89 ± 0.17c | 141 | 87.0 ± 2.9a | 3 |
| 5OH-AB-PINACA | 6.35 ± 0.06b | 452 | 3 | 5.55 ± 0.08c | 2742 | 100 ± 16.8a | 3 | – | – | – | |
EMAX and IMAX values are presented as the percent (%) of basal activity in the presence of vehicle. a,b,cpKi, pEC50, and pIC50 values designated by different letters are significantly different from values within the same column; P < 0.05, one-way ANOVA, Tukey’s post hoc test. †pKi and Ki values for CP-55,940 were obtained from that previously published in Ford et al. (2017a).