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. 2018 Sep 26;9:1116. doi: 10.3389/fphar.2018.01116

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Copyright © 2018 Kalimuthu, Gangadaran, Rajendran, Zhu, Oh, Lee, Gopal, Baek, Jeong, Lee, Lee and Ahn.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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In vivo therapeutic effect of PTX-MSC-EMs on MDA-MB-231/effluc breast cancer xenograft. (A) Fluc activity of breast cancer cells (MDA-MB-231/effluc) measured by BLI in mice treated with either MSC-EMs or PTX-MSC-EMs. BLI images were taken on days 1, 3, 5, and 8 in six mice. (B) Quantitative Fluc activity data shown in A. (C) Tumor weights at the end of the study. BLI activity is shown in photon flux (photons/sec [p/s]). ^∗p < 0.05 and ^∗∗p < 0.01 for comparison between control and MSC-PTX-EM group. ^#p < 0.05, ^##p < 0.01 for comparison between MSC-EM and MSC-PTX-EM group.