Figure 2.

Fingolimod treatment improves spatial and recognition memory deficits. (A,B) Spatial and (C,D) recognition memory were assessed with the (A,B) object placement test and (C,D) object recognition test. (A) The preference score of each mouse is reported as percent of total exploration time that is spent exploring (A) the object in a novel position and (C) the novel object. The dotted line denotes 55% preference, and a preference score above is considered “passing.” The percent of mice in each group with a passing score is reported for the object placement test (B) and object recognition test (D). Control treated n = 16; Fingolimod treated, n = 16. Two mice per group were excluded from the object recognition test for failure to explore for a minimum of 3 seconds during the training interval. ^*p < 0.05, ^**p < 0.01. Results are displayed as mean ± SEM.