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. 2018 Sep 26;9:2189. doi: 10.3389/fimmu.2018.02189

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Copyright © 2018 Mike, Makinde, Der, Stock, Gulinello, Gadhvi, Winter, Cuda and Putterman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Fingolimod significantly reduces CNS infiltration. (A) Coronal sections of brains from fingolimod treated mice and controls were stained with H&E, and the choroid plexus was blindly scored for lymphocytic infiltration (10x magnification). Representative sections are shown. (B) Immunofluorescent staining of CD4+ T cells (magenta) and CD8+ T cells (green) and quantification of cells per field at 20x magnification. (C) Iba1+ macrophages (magenta) were also quantified at 20x magnification. Control treated, n = 7; Fingolimod treated, n = 8. (D) Quantification of infiltrating T cells, macrophages, eosinophils, and natural killer cells by flow cytometry from hemisected brain lysates. Control treated, n = 10; Fingolimod treated, n = 7. ^*p < 0.05, ^**p < 0.01, ^***p < 0.001. Results are displayed as mean ± SEM.