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. 2018 Sep 26;9:2189. doi: 10.3389/fimmu.2018.02189

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Copyright © 2018 Mike, Makinde, Der, Stock, Gulinello, Gadhvi, Winter, Cuda and Putterman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Fingolimod reduces albumin leakage but has no effect on IgG deposition. (A) Leakage of serum albumin (red) around cortical vessels was quantified by mean fluorescent intensity at 20x magnification (B,C). Diffuse deposition of IgG (green) in the cortex (B) and hippocampus (C) was assessed by mean fluorescent intensity at 20x magnification to determine the intensity score. Representative sections are shown. Control treated, n = 7; Fingolimod treated, n = 8. ^*p < 0.05. Results are displayed as mean ± SEM.