Table 1.
Lists of proteins/cytokine expressed differentially between POD14 and POD63.
| Protein name | Accession number | Mw (kDa) | Fold changea | Biological function |
|---|---|---|---|---|
| Ceruloplasmin | P13635 | 123.67 | 9.42 ± 0.56 | It has ferroxidase activity oxidizing Fe2+ to Fe3+ without releasing radical oxygen species. May also play a role in fetal lung development or pulmonary antioxidant defense. |
| T-Kininogen I | P01048 | 47.76 | −2.78 ± 0.32 | They are inhibitor of thiol proteases. |
| Haptoglobin | P06866 | 38.56 | 6.56 ± 0.48 | Controlling the equilibrium between tolerance and immunity to non-self antigens. |
| MCP-1 (CCL2) | P14844 | 11.03 | 3.44 ± 0.84 | Chemotactic factor that attracts monocytes, but not neutrophils. |
| MIP-3α (CCL20) | P97884 | 8.0 | −1.34 ± 0.15 | Involved in the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells. |
| TIMP | P30120 | 23 | 5.17 ± 0.64 | As a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. |
| β-NGF | P25427 | 26 | 1.72 ± 0.39 | A critical role in the regulation of both innate and acquired immunity. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI. |
a
Fold change indicated alterations of protein volume POD63 vs. POD14, respectively. Differences were considered significant at *p < 0.05.