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. 2018 Sep 26;9:806. doi: 10.3389/fneur.2018.00806

Figure 2.

Figure 2

Basal ganglia GABA, prefrontal GABA and prefrontal Glx appear to be associated with axial symptom scores including gait and postural difficulties assessed with the MDS-UPDRS. (A) left basal ganglia GABA levels were significantly associated with higher axial symptom summary scores in akinetic-rigid (AKR) patients (p = 0.034), but not in tremor-dominant (TD) patients (p = 0.403), while the full patient group showed a trend-level association between basal ganglia GABA and axial summary scores (p = 0.067). (B) Elevated GABA levels were also associated higher gait summary scores (p = 0.038, full group). In the AKR subgroup, increased GABA levels were significantly positively associated with difficulties arising from a chair (C, p = 0.002) and difficulties with posture (D, p = 0.002). Left prefrontal GABA levels were negatively associated with postural stability in the AKR subgroup (p = 0.004, E), while left prefrontal Glx levels were negatively associated difficulties turning in bed, both in the full group (p = 0.029, F), and in the AKR subgroup (p = 0.041, F).