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. 2017 Oct 30;38(10):1727–1740. doi: 10.1177/0271678X17739219

Figure 4.

Figure 4.

Chronic exposure to HFSS results in significant elevation in systolic blood pressure (p = 0.013) (a) but no effect on heart rate (b). There was a complex interaction among independent variables with respect to glucose homeostasis measured ∼2 weeks prior to MRI assessment (c). HFSS animals were significantly different than control diet animals at both fasting and 30-min time points (*p < 0.01), HFSS + Sham animals expressed significantly lower glucose at 10-min post-glucose administration (#p < 0.03). There were no differences for the remaining time points. X-axis time data correspond to fasting glucose (overnight, 12 h), 10 -, 30- 60- and 120-min post-50% D-glucose infusion (1 g/kg, i.p.). There was no effect of diet on fasting insulin concentration (d). Cont+Sham – Control diet + Sham surgery; Cont+MD – Control diet + Mediodorsal thalamic stroke; HFSS+Sham – High Fat, Salt, Sugar diet + Sham surgery; HFSS+MD – High Fat, Salt, Sugar diet + Mediodorsal thalamic stroke.