Supplementary Table 3.

Definitions of Extrahepatic Organ Dysfunction

Organ	Definition of new dysfunction
Renal	Serum creatinine level increases by ≥50% as compared with serum creatinine level at baseline
Respiratory	Any single point increase in oxygen saturations divided by inspired oxygen as classified on the following scoring system compared with oxygen saturations divided by inspired oxygen at randomization: 0, >357; 1, >214 to ≤357; 2, ≤214 or mechanical ventilation
Circulatory	MAP decreases to <60 mm Hg, OR patient is started on inotropic/vasopressor support If the patient has MAP < 60 mm Hg at baseline, they will need to be started on inotropic/vasopressor support to reach this end point
Cerebral	Grade III (drowsy) or grade IV encephalopathy (coma) using the Westhaven criteria to grade hepatic encephalopathy If the patient has grade III encephalopathy (somnolent but rousable at baseline), they will need to progress to grade IV to reach this end point

NOTE. Organ dysfunction at baseline was determined according to the following criteria: renal, creatinine level > 133 μmol/L; respiratory, oxygen saturations divided by inspired oxygen < 357; circulatory, MAP < 60 mm Hg or patient is receiving inotropic/vasopressor support; cerebral, grade III or IV encephalopathy.

MAP, mean arterial pressure.