Supplementary Table 9.

Outcomes for Individual Patients Who Triggered the Planned Composite End Point for the RCT

First component recorded	Day	Subsequent or concurrent component	Day	Subsequent or concurrent component	Day	Days in hospital, n	Days from composite endpoint to discharge, n	Alive at 30 days
Respiratory	13					13	0	Yes
Respiratory	7					23	16	Yes
Respiratory	15					16	1	Yes
Respiratory	8					23	15	No
Respiratory	3					12	9	Yes
Respiratory	9					17	8	Yes
Respiratory	4					6	2	Yes
Respiratory	3	Infection	9			15	12	Yes
Respiratory	3	Infection	5			28	25	Yes
Respiratory	3	Infection	6			17	14	Yes
Respiratory	3	Death	3			3	0	No
Respiratory	3	Infection	5	Circulation	9	23	20	Yes
Circulatory	6					15	9	Yes
Circulatory	9					21	12	Yes
Circulatory	3					3	0	Yes
Circulatory	3					6	3	Yes
Circulatory	3					15	12	Yes
Circulatory	9					14	5	Yes
Circulatory	4	Infection	8			32	28	Yes
Circulatory	11	Infection	15			27	16	Yes
Circulatory	10	Renal	12			14	8	Yes
Renal	3					11	8	Yes
Renal	3	Infection	4	Death	5	5	2	No
Renal	5	Infection + respiratory + circulatory	8	Cerebral	9	24	19	No
Infection	3					31	28	No
Infection	11					18	7	Yes
Infection	8					13	5	Yes
Infection	3					22	19	Yes
Infection	13					43	30	Yes
Infection	3					88	85	Yes
Infection	13	Respiratory	13			101	88	Yes
Infection	3	Respiratory	3			23	20	No
Infection	3	Circulatory	10			14	11	Yes
Infection	7	Renal	14	Death	15	15	8	No
Infection	3	Circulatory	5	Respiratory	6	34	31	Yes
Infection	3	Respiratory + circulatory	3	Renal	4	13	10	No
Infection	3	Respiratory + circulatory	3	Renal Death	5 10	10	7	No
Death	6					6	1	No