Figure 4.

Bull’s-eye schematic of observed WMH lesion frequency (a), and lesion distribution (b), within different brain regions and layers in the cadaveric MRI brain scan. Each region of the brain is apportioned into four layers, with the ventricle represented at the center of the diagram and the cortical sheet at the external edge. Lesion frequency is the proportion of the volume of a brain region taken up by WMH. Lesion distribution is the proportion of the total brain WMH lesion load present in that region. Degree of lesion frequency and distribution are represented using a color scale bar. FRONT frontal lobes, PAR parietal lobes, TEMP temporal lobes, OCC occipital lobes, BGIT basal ganglia and thalami.