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. 2018 Oct;188(10):2339–2355. doi: 10.1016/j.ajpath.2018.06.022

Figure 2.

Figure 2

Persistent hepatitis C virus (HCV) replication in Huh-7.5 cells induces nuclear factor erythroid 2–related factor (Nrf2) activation and nuclear translocation. A: Immunocytochemical staining of core protein in HCV-infected Huh-7.5 cells at different days after HCV infection. B: Quantification of core-positive infected Huh-7.5 cells. Three high-power fields (HPFs) were measured using ImageJ version 1.52c. C: Immunocytochemical staining of phosphorylated Nrf2 (pNrf2) in HCV-infected Huh-7.5 cells at different days after HCV infection. D: Quantification of nuclear Nrf2-positive infected Huh-7.5 cells; three high-power fields were measured using ImageJ. ∗∗∗∗P < 0.0001 versus day 0. Scale bars = 200 μm (A and C).