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. 2018 Oct;188(10):2264–2280. doi: 10.1016/j.ajpath.2018.06.015

Figure 8.

Figure 8

A: In human hepatic stellate cell lines (HHSteCs) treated with cholangiocyte supernatant from secretin-treated wild-type (WT) mice, there is increased expression of fibrosis but reduced expression of senescence genes, changes that are reversed by preincubation of HHSteCs with LY2109761; no effects were observed with normal cholangiocyte supernatant. Data are from three evaluations. B: Transforming growth factor (TGF)-β1 stimulates fibrosis gene expression but reduces senescence gene expression in HHSteCs. Data are from three experiments from three individual preparations of HHSteCs. Data are expressed as means ± SEM (A and B). ∗P < 0.05 versus HHSteCs treated with normal cholangiocyte supernatant; †P < 0.05 versus HHSteCs treated with bile duct ligated cholangiocyte supernatant; ‡P < 0.05 versus basal value. Col1a1, collagen I; Fn1, fibronectin 1; α-SMA, α-smooth muscle actin; TGF-β1R, TGF-β1 receptor.