Table 2.

Retinoblastoma Characteristics

Anaplastic grade	Sample	HRPF	Distant metastasis	Secondary tumors	RB1 mutation	Laterality	Age at diagnosis (months)	Follow-up period (months)
Mild	RB 3	No	No	No	ND	Bilateral	3	120
	RB 5	Postlaminar ON	No	Pinealoma	G	Bilateral	1	56
	RB 6	No	No	No	ND	Bilateral	2	69
	RB 7	Postlaminar ON, massive choroidal invasion	No	No	G	Bilateral	1	10
	RB 19	No	No	No	ND	Unilateral	11	81
	RB 23	No	No	No	NG	Unilateral	17	42
Moderate	RB 1	No	No	RCC	ND	Bilateral	3	212
	RB 2	No	No	No	ND	Bilateral	10	179
	RB 4	No	No	No	ND	Bilateral	4	186
	RB 8	No	No	No	G	Bilateral	4	141
	RB 9	No	No	No	G	Unilateral	11	96
	RB 11	Postlaminar ON	No	No	ND	Unilateral	4	71
	RB 14	Postlaminar ON, massive choroidal invasion	Brain	No	ND	Unilateral	28	22
	RB 16	Massive choroidal invasion	Bone	No	ND	Unilateral	24	140
	RB 17	No	No	No	G	Unilateral	21	76
	RB 18	No	No	No	NG	Unilateral	2	91
	RB 22	No	No	No	NG	Unilateral	11	16
	RB 26	No	No	No	ND	Bilateral	26	138
	RB 31	No	No	No	None	Unilateral	23	64
Severe	RB 12	Postlaminar ON	No	No	ND	Unilateral	18	45
	RB 13	Postlaminar ON, massive choroidal invasion	No	No	G	Unilateral	27	78
	RB 21	Postlaminar ON, massive choroidal invasion	No	No	NG	Unilateral	34	35
	RB 24	No	Bone, Liver	No	NG	Unilateral	19	19
	RB 25	No	No	No	NG	Unilateral	28	40
	RB 28	Laminar ON, nonmassive choroidal invasion	No	No	NG	Unilateral	46	58
	RB 30	No	Liver, Bone marrow	No	NG	Unilateral	27	9
	RB 32	No	No	No	NG	Unilateral	54	43
	RB 33	Massive choroidal invasion	No	No	NG	Unilateral	37	12

G, germline; ND, not determined; NG, nongermline; ON, optic nerve invasion; RB, retinoblastoma; RCC, renal cell carcinoma.