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. 2018 Oct;188(10):2328–2338. doi: 10.1016/j.ajpath.2018.06.013

Table 3.

Four Genes Perfectly Separate Severe from Mild and Moderate Anaplasia

Symbol Name log2FC padj Function
EXOC8 Exocyst complex component 8 0.896602312 0.000127061 Regulates exocytosis by tethering post-Golgi vesicles to the plasma membrane
Associated with Ras-mediated oncogenesis39
CHTOP Chromatin target of PRMT1 0.937928804 0.000500989 Small nuclear protein involved in glioblastomagenesis40
NUCKS1 Nuclear casein kinase and cyclin-dependent kinase substrate 1 1.126599037 0.051952553 Chromatin-associated protein involved in DNA repair and homologous recombination41
ADSS Adenylosuccinate synthase 0.931391858 0.000574213 Catalyzes the conversion of inosine monophosphate to adenosine monophosphate42

FC, fold change; padj, P value adjusted for multiple comparisons.