Figure 1.

Dysregulation of diurnal expression of core clock genes in several tissues of pre-symptomatic SMA mice. Diurnal expression of core clock genes (Clock, Bmal1, Per1, Per2, Cry1 and Cry2) in TA, WAT, BAT, liver, heart and SC of postnatal day (P) 2 Smn^−/−;SMN2 mice compared to healthy littermates. Data are mean ± SEM, n = 3–5 mice per ZT, ^*P-value < 0.05, ^**P-value < 0.01, ^***P-value < 0.001, ^****P-value < 0.0001 (two-way ANOVA), # indicates circadian rhythmicity. ZT1 data are duplicated.