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. 2018 Aug 14;27(20):3582–3597. doi: 10.1093/hmg/ddy249

Figure 3.

Figure 3

Dysregulation of diurnal expression of clock output genes in several tissues of pre-symptomatic and symptomatic SMA mice. Diurnal expression of clock output genes (Nr1d1, Dbp,) in TA, WAT, BAT, liver, heart and SC of postnatal day (P) 2 (A) and P7 (B) Smn−/−;SMN2 mice compared to healthy littermates. P2 data are mean ± SEM, n = 3–5 mice per ZT, P7 data are mean ± SEM, n = 3–4 per ZT, *P-value < 0.05, **P-value < 0.01, ***P-value < 0.001 (two-way ANOVA), # indicates circadian rhythmicity. ZT1 data are duplicated.