Figure 8.

Light modulation impacts certain canonical pathological markers of SC and muscle pathology of SMA mice. TA and SC were harvested from postnatal (P) 7 Smn^−/−;SMN2 mice (n = 7 for RL and 3 for CL) and healthy littermates (n = 5 for RL and 6 for CL) in CL and RL conditions at ZT1 (9 am). Expression of MuRF-1 (A) and atrogin-1 (B) in TA of P7 Smn^−/−;SMN2 mice and healthy littermates from RL and CL. Expression of Fas (C) and Pmaip1 (D) in SC of P7 Smn^−/−;SMN2 mice and healthy littermates from RL and CL. Data are mean ± SEM, ^*P-value < 0.05, ^**P-value < 0.01, ns = not significant (one-way ANOVA).