Table 1.
Function, protein class, Reactome pathway and GO biological process complete of dysregulated genes in P7 BAT from RL SMA mice generated with Panther software
| Genes dysregulated in SMA mice RL | Fold enrichment | P-value | |
|---|---|---|---|
| Molecular Function | Protein kinase activity | 8.16 | 1.40E-02 |
| Sequence-specific DNA binding transcription factor activity | 4.64 | 1.51E-02 | |
| Protein class | Non-receptor serine/threonine protein kinase | 11.78 | 1.24E-02 |
| Transcription factor | 5.41 | 5.06E-04 | |
| Reactome pathway | RORA activates gene expression | >100 | 3.14E-09 |
| Degradation of GLI2 by the proteasome | >100 | 2.35E-02 | |
| PPARA activates gene expression | >100 | 2.35E-02 | |
| Rora activates gene expression | >100 | 8.55E-09 | |
| Bmal1:Clock,Npas2 activates circadian gene expression | >100 | 9.35E-15 | |
| WNT mediated activation of DVL | >100 | 3.35E-04 | |
| PKA activation | >100 | 1.07E-05 | |
| PKA activation in glucagon signalling | >100 | 1.38E-05 | |
| DARPP-32 events | >100 | 2.21E-05 | |
| Trafficking of AMPA receptors | 69.76 | 1.73E-02 | |
| Vasopressin regulates renal water homeostasis via Aquaporins | 68.05 | 5.81E-04 | |
| Post NMDA receptor activation events | 63.41 | 2.29E-02 | |
| Factors involved in megakaryocyte development and platelet producti | 28.77 | 1.72E-02 | |
| MAPK family signaling cascades | 14.65 | 3.23E-02 | |
| Developmental Biology | 8.53 | 4.49E-03 | |
| GO biological process complete | Negative regulation of glucocorticoid receptor signaling pathway | >100 | 7.65E-04 |
| Development of secondary female sexual characteristics | >100 | 3.53E-03 | |
| Protein-chromophore linkage | >100 | 4.69E-03 | |
| Circadian regulation of gene expression | >100 | 9.62E-15 | |
| Entrainment of circadian clock by photoperiod | >100 | 2.40E-02 | |
| Circadian behavior | 95.12 | 3.71E-02 | |
| Peptidyl-serine phosphorylation | 25.37 | 1.00E-03 | |
| Positive regulation of sequence-specific DNA binding transcription fact | 19.84 | 4.18E-03 | |
| Cellular response to hormone stimulus | 15.5 | 2.72E-04 | |
| Morphogenesis of an epithelium | 10.09 | 3.76E-02 | |
| Embryonic morphogenesis | 9.47 | 1.12E-02 | |
| Cellular response to oxygen-containing compound | 8.52 | 2.46E-02 | |
| Regulation of secretion by cell | 8.29 | 3.00E-02 | |
| Positive regulation of transcription from RNA polymerase II promoter | 8.06 | 7.77E-05 | |
| Negative regulation of developmental process | 7.21 | 2.07E-02 | |
| Transcription, DNA-templated | 4.8 | 6.82E-03 | |
| Regulation of multicellular organismal process | 4.16 | 1.35E-03 | |
| Regulation of cellular protein metabolic process | 4.16 | 3.42E-02 | |
| Regulation of biological quality | 3.41 | 2.07E-02 | |