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. 2018 Oct;188(10):2223–2235. doi: 10.1016/j.ajpath.2018.06.009

Figure 2.

Figure 2

Lobular size and cell volume in EGFRi, ΔMET + EGFRi, and ΔMET mice. A: The mean average hepatocyte volume in EGFRi and/or ΔMET mouse compared with control. B: Representative glutamine synthase immunohistochemistry left to right from day 10 control, EGFRi, ΔMET + EGFRi, and ΔMET mice. The one layer of cells surrounding the central vein of each lobule is marked as positive for glutamine synthase. The distance between the marked areas demonstrates the decreased lobular dimensions in the ΔMET + EGFRi mice at day 10. Images taken using a 5× objective. Data are expressed as means ± SEM (A). ∗∗∗∗P ≤ 0.0001 versus control.