Table 2.

Biological Process (GO Terms) Significantly Enriched in Clusters 1, 2, and 5 (Top to Bottom) Analyzed Using PANTHER Overrepresentation Test and Compared with the Mus musculus Reference List

PANTHER GO biological process	Reference gene no.	Cluster gene no.	Fold enrichment	P value
Cluster 1
Oxidative phosphorylation	48	10	11.62	5.97 × 10−6
Generation of precursor metabolites and energy	161	21	7.28	9.11 × 10−10
Respiratory electron transport chain	124	15	6.75	2.95 × 10−6
Coenzyme metabolic process	67	8	6.66	8.26 × 10−3
Cellular amino acid biosynthetic process	61	7	6.4	3.23 × 10−2
Cellular amino acid metabolic process	222	20	5.03	1.60 × 10−6
Fatty acid metabolic process	210	13	3.45	3.25 × 10−2
Lipid metabolic process	620	33	2.97	1.04 × 10−5
Primary metabolic process	4367	146	1.87	5.67 × 10−13
Metabolic process	5460	166	1.7	1.25 × 10−11
Nitrogen compound metabolic process	2357	68	1.61	1.45 × 10−2
Cluster 2
Cellular component biogenesis	496	18	3.87	3.18 × 10−4
Apoptotic process	445	16	3.83	1.40 × 10−3
Death	466	16	3.66	2.47 × 10−3
Cell death	466	16	3.66	2.47 × 10−3
Cellular component organization or biogenesis	1655	33	2.12	8.11 × 10−3
Metabolic process	5460	82	1.6	4.33 × 10−4
Cellular process	8341	104	1.33	4.54 × 10−2
Cluster 5
Coenzyme metabolic process	67	7	9.12	3.50 × 10−3
Steroid metabolic process	120	8	5.82	2.04 × 10−2
Fatty acid metabolic process	210	11	4.57	8.98 × 10−3
Lipid metabolic process	620	25	3.52	1.73 × 10−5
Carbohydrate metabolic process	340	13	3.34	4.27 × 10−2
Metabolic process	5460	92	1.47	6.01 × 10−3

Statistical analysis was performed using Fisher's exact test with false discovery rate multiple test correction.

GO, gene ontology.