Table 1.
Litters produced from mice maintained on vitamin B12-supplemented or vitamin B12-deficient diet
| Breeding Cross Female X Male | Dietary Vit. B12 | # dams Mated | # litters | Mean pups/litter | S.D. | P-value* | ||
|---|---|---|---|---|---|---|---|---|
| 1 | Control | Control | + | 4 | 22 | 5.27 | 2.59 | |
| 2 | Control | Control | - | 6 | 18 | 4.39 | 2.06 | 0.25 |
| 3 | KO | KO | + | 7 | 27 | 3.96 | 2.18 | 0.066 |
| 4 | KO | KO | - | 14 | 0 | n/a | n/a | |
| 5 | Control | KO | - | 2 | 9 | 4.33 | 2.87 | |
| 6 | KO | Control | - | 4 | 0 | n/a | n/a | |
| 7 | KO | Control/KO | - | 3 | 0 | n/a | n/a | |
*Two tailed t-test compared to the control mice on vitamin B12-replete diet in line 1