Table 5.

Cox proportional hazard model regression analysis

	Hazard ratios (HR) with 95% CI
	Unadjusted model	Adjusted model 1	Adjusted model 2
	HR	HR	HR
Frontal signs
Mildly-impaired	1.2 (1.1–1.2)	1.1 (1.1–1.2)	1.1 (1.1–1.2)
Heavily-impaired	2.1 (2.0–2.3)	1.9 (1.7–2.1)	1.6 (1.4–1.8)
Extrapyramidal signs
Mildly-impaired	1.3 (1.2–1.3)	1.2 (1.1–1.2)	1.1 (1.1–1.2)
Heavily-impaired	1.9 (1.7–2.1)	1.7 (1.5–1.9)	1.4 (1.3–1.6)
Cerebellar signs
Mildly-impaired	1.5 (1.4–1.6)	1.4 (1.3–1.5)	1.3 (1.2–1.4)
Heavily-impaired	1.7 (1.5–1.9)	1.6 (1.4–1.7)	1.3 (1.1–1.5)
Gait disturbance signs
Mildly-impaired	1.1 (1.0–1.3)	1.0 (0.9–1.2)	1.0 (0.8–1.1)
Heavily-impaired	1.1 (1.0–1.2)	1.1 (1.0–1.1)	1.0 (0.9–1.0)

Multivariate prediction analysis of mortality at follow up by four factor scores derived from the NEUROEX assessment at baseline. Hazard ratios (HR) pooled over countries (with 95% CI) are shown for an unadjusted model, a model adjusted for socio-demographical variables (adjusted for gender, educational level and age; adjusted model 1) and a model adjusted for socio-demographical variables and general indicators of health status (adjusted for gender, educational level, age, depression, clinically diagnosed stroke, diabetes, hypertension and dementia; adjusted model 2)