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. 2018 Oct 3;20:219. doi: 10.1186/s13075-018-1722-9

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Effects of CYLD on cell proliferation, apoptosis, and cell cycle in RA-FLSs. We transfected RA-FLSs with sh-CYLD or sh-GFP. (A) CCK-8 test showed increased RA-FLSs proliferation in the sh-CYLD transfection group compared with the sh-GFP transfection group. (B) FCM analysis demonstrating the effect of CYLD suppression on cell apoptosis. (C) FCM analysis demonstrating the effect of CYLD suppression on cell cycle progression. Data are represented as mean ± SD from 3 independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001