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. 2018 Jun 12;6(8):1223–1231. doi: 10.1177/2050640618784053

Table 3.

Sensitivity and specificity of hemoglobin and transferrin at preset and adjusted thresholds.

Fecal marker Hemoglobin Transferrin Hemoglobin Transferrin
Threshold (µg marker/g feces) 6.3 3.3 9.88a 2.28a
Participants of screening colonoscopy only (n = 516)
 Specificity (%) (95% CI)
 No advanced neoplasm (n = 300) 91.3 (88–94) 97.3 (95–99) 95.0 (92–97) 95.0 (92–97)
 Sensitivity (%) (95% CI)
 CRC (n = 16) 81.3 (54–96) 37.5 (15–65) 68.8 (41–89) 43.8 (20–70)
 AA (n = 200) 31.0 (25–38) 6.5 (4–11) 21.5 (16–28) 12.0 (8–17)
 Distal AA only (n = 98) 28.6 (20–39) 6.1 (2–13) 18.4 (11–27) 9.2 (4–17)
 Proximal AA only (n = 49) 24.5 (13–39) 0.0 (0–0) 16.3 (7–30) 10.2 (3–22)
 Distal and proximal AAs (n = 53) 41.5 (28–56) 13.2 (5–25) 32.1 (20–46) 18.9 (9–32)
 CRC or AA (n = 216) 34.7 (28–41) 8.8 (5–13) 25.0 (19–31) 14.4 (10–20)
Screening and clinical CRC cases combined (n = 66)
 Sensitivity (%) (95% CI)
 CRC (n = 66) 75.8 (64–85) 39.4 (28–51) 68.2 (56–79) 43.9 (32–57)
 Distal CRC only (n = 43) 76.7 (61–88) 44.2 (29–60) 69.8 (54–83) 48.8 (33–65)
 Proximal CRC only (n = 22) 72.7 (50–89) 27.3 (11–50) 63.6 (41–83) 31.8 (14–55)
a

Adjusted threshold.

AA: advanced adenoma; CI: confidence interval; CRC: colorectal cancer.