Table 3.
Fecal marker | Hemoglobin | Transferrin | Hemoglobin | Transferrin |
---|---|---|---|---|
Threshold (µg marker/g feces) | 6.3 | 3.3 | 9.88a | 2.28a |
Participants of screening colonoscopy only (n = 516) | ||||
Specificity (%) (95% CI) | ||||
No advanced neoplasm (n = 300) | 91.3 (88–94) | 97.3 (95–99) | 95.0 (92–97) | 95.0 (92–97) |
Sensitivity (%) (95% CI) | ||||
CRC (n = 16) | 81.3 (54–96) | 37.5 (15–65) | 68.8 (41–89) | 43.8 (20–70) |
AA (n = 200) | 31.0 (25–38) | 6.5 (4–11) | 21.5 (16–28) | 12.0 (8–17) |
Distal AA only (n = 98) | 28.6 (20–39) | 6.1 (2–13) | 18.4 (11–27) | 9.2 (4–17) |
Proximal AA only (n = 49) | 24.5 (13–39) | 0.0 (0–0) | 16.3 (7–30) | 10.2 (3–22) |
Distal and proximal AAs (n = 53) | 41.5 (28–56) | 13.2 (5–25) | 32.1 (20–46) | 18.9 (9–32) |
CRC or AA (n = 216) | 34.7 (28–41) | 8.8 (5–13) | 25.0 (19–31) | 14.4 (10–20) |
Screening and clinical CRC cases combined (n = 66) | ||||
Sensitivity (%) (95% CI) | ||||
CRC (n = 66) | 75.8 (64–85) | 39.4 (28–51) | 68.2 (56–79) | 43.9 (32–57) |
Distal CRC only (n = 43) | 76.7 (61–88) | 44.2 (29–60) | 69.8 (54–83) | 48.8 (33–65) |
Proximal CRC only (n = 22) | 72.7 (50–89) | 27.3 (11–50) | 63.6 (41–83) | 31.8 (14–55) |
Adjusted threshold.
AA: advanced adenoma; CI: confidence interval; CRC: colorectal cancer.