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. 2018 Oct 3;37:240. doi: 10.1186/s13046-018-0899-8

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 8 — Effects of FL118 on animal body weight changes during treatment: a, Effects of FL118 on the body weight change of BALB/cj mice. Results from vehicle and FL118 MTD dosing level (10 mg/kg) were shown with oral route via qw × 4 (arrowed). The body weigh curves were derived from the mean ± SD derived from 6 independent BALB/cj mice. b and c, Effects of FL118 on the body weight change of beagle dogs. Results from vehicle and FL118 at 0.55 mg/kg (1/4MTD), 1.1 mg/kg (1/2MTD) and 2.2 mg/kg (MTD) dosing levels were shown with oral administration of FL118 on Days 1 and 8. The body weigh histograms were derived from the mean ± SD derived from 2 male or 2 female beagle dogs