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. 2018 Oct 2;16:109. doi: 10.1186/s12915-018-0576-6

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© Lallemand et al. 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Concomitant expression of WWOX and VOPP1 in human breast tumors. a The 448 breast cancer patients were classified into two groups (low WWOX (< 0.6), n = 193; and high WWOX (≥ 0.6), n = 255), and the proportion of tumors expressing high (≥ 2.5) or low levels (< 2.5) of VOPP1 was assessed in each group. Statistical significance was calculated by the chi-square test (b). Kaplan-Meier curves showing metastasis-free survival rates of patients with tumors expressing high (red line) vs. low (blue line) VOPP1/WWOX ratio in subpopulations of patients with low or high WWOX levels. c Multivariate Cox proportional hazards analysis showing the independence of the VOPP1/WWOX expression ratio in the prognosis of breast cancer patients retaining WWOX expression (HR, hazard ratio; CI, confidence interval)