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. 2018 Oct 1;12(1):84–95. doi: 10.1016/j.tranon.2018.09.011

Figure 3.

Figure 3

siRNA knockdown of I2PP2A and CIP2A decreased cell proliferation. (A) Neuroblastoma cell lines were treated with I2PP2A siRNA (siSET) or control siRNA (siNeg) for 48 hours, and proliferation was measured with CellTiter 96 assay. Proliferation was significantly decreased in the SK-N-AS and the WAC2 cell lines. (B) Neuroblastoma cell lines were treated with CIP2A siRNA (siCIP2A) or control siRNA (siNeg), and cell proliferation was measured. Proliferation was significantly decreased in all four cell lines after CIP2A knockdown. (C) Neuroblastoma cell lines were treated with both I2PP2A and CIP2A siRNA (siDual) or control siRNA (siNeg), and proliferation was measured. Proliferation was significantly decreased in all four cell lines. Experiments were repeated at least in triplicate and reported as mean fold change ± SEM.