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. 2018 Oct;188(10):2281–2292. doi: 10.1016/j.ajpath.2018.06.011

Figure 7.

Figure 7

IL-1β–induced changes in regulated on activation normal T cell expressed and secreted [RANTES; chemokine (C-C motif) ligand 5] secretion. Triplicate eutopic endometriosis stromal cell (EESC) cultures were incubated for 24 hours without (control) or with IL-1β. A: Preincubation with a 100-fold molar excess of IL-1ra completely prevented IL-1β–induced RANTES secretion. B: Preincubation with the NF-κB inhibitor SN50 afforded a 34% suppression of IL-1β–induced RANTES, but there was no inhibition (<2%) with the inert peptide SN50M. The c-Jun N-terminal kinase (JNK) blocker, SP600125, inhibited IL-1β–induced effects on RANTES by 79% [P < 0.05, analysis of variance with Scheffé’s post hoc test (all conditions were different from IL-1β except SN50M + IL-1β)] (C). Similar findings were noted in independent EESC preparations. n = 3 independent EESC preparations (C).