Table 4.
Twenty eight-day efficacy of AA, AL, or DHP according to study sites
| PCR-uncorrected on day 28 | PCR-corrected on day 28 | |||||||
| Study sites | ACRP_u | Failure_u | Total | % Cure rate | ACPR_c | Recrudescence | Total | % Recrudescence |
| All treatments | ||||||||
| Numan (Adamawa) | 154 | 12 | 166 | 92.8 | 144 | 6 | 150 | 4 |
| Neni (Anambra) | 35 | 9 | 44 | 79.5 | 16 | 0 | 16 | 0 |
| Otuasegha (Bayelsa) | 76 | 7 | 83 | 91.6 | 72 | 1 | 73 | 1.4 |
| Ogwa (Imo) | 142 | 9 | 151 | 94 | 93 | 0 | 93 | 0 |
| Kura (Kano) | 155 | 5 | 160 | 96.9 | 142 | 0 | 142 | 0 |
| Ilorin (Kwara) | 66 | 5 | 71 | 93 | 34 | 0 | 34 | 0 |
| Ibadan (Oyo) | 46 | 1 | 47 | 97.9 | 44 | 0 | 44 | 0 |
| Bodinga (Sokoto) | 116 | 11 | 127 | 91.3 | 43 | 1 | 44 | 2.3 |
| All sites | 790 | 59 | 849 | 93.1 | 588 | 8 | 596 | 1.5 |
| AA | ||||||||
| Numan (Adamawa) | 52 | 3 | 55 | 94.5 | 46 | 2 | 48 | 4.2 |
| Neni (Anambra) | 8 | 5 | 13 | 61.5 | 4 | 0 | 5 | 0 |
| Otuasegha (Bayelsa) | 27 | 3 | 30 | 90 | 24 | 1 | 25 | 4 |
| Ogwa (Imo) | 49 | 5 | 54 | 90.7 | 35 | 0 | 35 | 0 |
| Kura (Kano) | 52 | 0 | 52 | 100 | 45 | 0 | 45 | 0 |
| Ilorin (Kwara) | 16 | 2 | 18 | 88.9 | 10 | 0 | 10 | 0 |
| Ibadan (Oyo) | 12 | 1 | 13 | 92.3 | 11 | 0 | 11 | 0 |
| Bodinga (Sokoto) | 35 | 6 | 41 | 85.4 | 14 | 1 | 15 | 6.7 |
| All sites | 251 | 25 | 276 | 90.9 | 189 | 4 | 193 | 2.1 |
| AL | ||||||||
| Numan (Adamawa) | 47 | 9 | 56 | 83.9 | 47 | 4 | 51 | 7.8 |
| Neni (Anambra) | 10 | 2 | 12 | 83.3 | 5 | 0 | 5 | 0 |
| Otuasegha (Bayelsa) | 21 | 2 | 23 | 91.3 | 22 | 0 | 22 | 0 |
| Ogwa (Imo) | 46 | 2 | 48 | 95.8 | 23 | 0 | 23 | 0 |
| Kura (Kano) | 50 | 5 | 55 | 90.9 | 50 | 0 | 50 | 0 |
| Ilorin (Kwara) | 20 | 3 | 23 | 87 | 9 | 0 | 9 | 0 |
| Ibadan (Oyo) | 15 | 0 | 15 | 100 | 14 | 0 | 14 | 0 |
| Bodinga (Sokoto) | 44 | 2 | 46 | 95.7 | 17 | 0 | 17 | 0 |
| All sites | 253 | 25 | 278 | 91 | 187 | 4 | 191 | 2.1 |
| DHP | ||||||||
| Numan (Adamawa) | 55 | 0 | 55 | 100 | 51 | 0 | 51 | 0 |
| Neni (Anambra) | 17 | 2 | 19 | 89.5 | 7 | 0 | 7 | 0 |
| Otuasegha (Bayelsa) | 28 | 2 | 30 | 93.3 | 26 | 0 | 26 | 0 |
| Ogwa (Imo) | 47 | 2 | 49 | 95.9 | 35 | 0 | 35 | 0 |
| Kura (Kano) | 53 | 0 | 53 | 100 | 47 | 0 | 47 | 0 |
| Ilorin (Kwara) | 30 | 0 | 30 | 100 | 15 | 0 | 15 | 0 |
| Ibadan (Oyo) | 19 | 0 | 19 | 100 | 19 | 0 | 19 | 0 |
| Bodinga (Sokoto) | 37 | 3 | 40 | 92.5 | 12 | 0 | 12 | 0 |
| All sites | 286 | 9 | 295 | 96.9 | 212 | 0 | 212 | 0 |
AA = artesunate–amodiaquine; ACPR_c = adequate clinical and parasitological response corrected; ACPR_u = adequate clinical and parasitological response uncorrected; AL = artemether–lumefantrine; DHP = dihydroartemisinin–piperaquine; Failure_u = treatment failure uncorrected; PCR = polymerase chain reaction.