Table 1.
Baseline descriptive characteristics of the study sample by randomization arm
| Amoxicillin household | Azithromycin household | Cotrimoxazole household | Placebo household | ||||
|---|---|---|---|---|---|---|---|
| Antibiotic (N = 31) | Placebo (N = 31) | Antibiotic (N = 31) | Placebo (N = 31) | Antibiotic (N = 31) | Placebo (N = 31) | N = 62 | |
| Age, months, median (IQR) | 35 (23–52) | 36 (26–53) | 29 (21–51) | 42 (30–47) | 37 (23–48) | 40 (23–50) | 38 (30–49) |
| Female gender, N (%) | 14 (45.2) | 18 (58.1) | 18 (58.1) | 12 (38.7) | 20 (64.5) | 19 (61.3) | 24 (38.7) |
| Weight, kg, median (IQR) | 12.1 (10.8–14.9) | 11.8 (10.9–14.6) | 12.2 (9.2–13.6) | 13.2 (11.3–15) | 12.9 (10.4–14.6) | 12.5 (9.7–14.5) | 13.4 (11.4–14.9) |
| Height, cm, median (IQR) | 88.4 (83–100.9) | 90.1 (82.7–98.7) | 86.6 (80.2–94.9) | 93.8 (85.3–98.9) | 90.2 (79.6–98.8) | 90 (82.6–96) | 92.5 (86.5–99.5) |
| WHZ, median (IQR) | −0.40 (−1.02 to 0.07) | −0.63 (−1.56 to 0.81) | −0.68 (−1.54 to 0) | −0.15 (−1.17 to 0.08) | −0.22 (−0.83 to 0.48) | −0.48 (−1.78 to 0.39) | −0.29 (−0.83 to 0.35) |
| HAZ, median (IQR) | −1.01 (−2.05 to −0.34) | −1.15 (−1.89 to −0.48) | −1.29 (−2.15 to −0.52) | −1.20 (−1.99 to −0.43) | −1.16 (−1.70 to −0.57) | −1.50 (−2.25 to −0.77) | −0.95 (−1.50 to −0.29) |
| WAZ, median (IQR) | −0.78 (−1.67 to −0.41) | −0.95 (−1.35 to −0.63) | −1.19 (−1.91 to −0.51) | −0.94 (−1.44 to −0.29) | −0.88 (−1.17 to −0.19) | −1.45 (−2.22 to −0.50) | −0.66 (−1.27 to −0.20) |
| MUAC, mm, median (IQR) | 150 (146–154) | 147 (143–160) | 147 (140–158) | 150 (145–159) | 150 (147–162) | 145 (140–163) | 155 (146–163) |
| Wasted, N (%)* | 2 (6.7) | 3 (9.7) | 2 (6.5) | 3 (9.7) | 2 (6.5) | 7 (22.6) | 6 (9.7) |
| Stunted, N (%)† | 8 (25.8) | 7 (22.6) | 8 (25.8) | 7 (22.6) | 4 (12.9) | 11 (35.5) | 7 (11.3) |
| Underweight, N (%)‡ | 5 (16.1) | 3 (9.7) | 4 (12.9) | 4 (12.9) | 3 (9.7) | 10 (32.3) | 6 (9.7) |
| Visited healthcare facility in past 30 days, N (%) | 6 (19.4) | 2 (6.5) | 4 (12.9) | 2 (6.5) | 6 (19.5) | 8 (25.8) | 14 (22.6) |
| Diarrhea§ | 1 (3.2%) | 0 | 0 | 0 | 0 | 0 | 1 (1.6%) |
| Cough§ | 0 | 0 | 0 | 0 | 1 (3.2%) | 0 | 0 |
| Fever§ | 0 | 0 | 0 | 1 (3.2%) | 0 | 0 | 2 (3.2%) |
cm = centimeters; HAZ = height-for-age Z score; IQR = interquartile range; kg = kilograms; mm = millimeters; MUAC = mid-upper arm circumference; WAZ = weight-for-age Z score; WHZ = weight-for-height Z score.
*
Defined as WHZ < −2 SD.
†
Defined as HAZ < −2 SD.
‡
Defined as WAZ < −2 SD.
§
Assessed on first treatment day, by caregiver report.