Table 3.
Growth and anthropometric indices in each antibiotic group compared with placebo 4 weeks after last antibiotic dose
| Amoxicillin (mean difference, 95% CI) | Azithromycin (mean difference, 95% CI) | Cotrimoxazole (mean difference, 95% CI) | ||||
|---|---|---|---|---|---|---|
| Vs. Placebo household | Vs. Placebo sibling | Vs. Placebo household | Vs. Placebo sibling | Vs. Placebo household | Vs. Placebo sibling | |
| Change in weight, g* | 317 (115–519) | 315 (147–482) | 46 (−151 to 243) | −52 (−209 to 106) | −31 (−219 to 157) | −4 (−251 to 243) |
| Weight gain, g/kg/day† | 0.79 (0.33–1.22) | 0.74 (0.37–1.10) | 0.12 (−0.36 to 0.59) | −0.15 (−0.53 to 0.23) | −0.05 (−0.46 to 0.37) | −0.05 (−0.65 to 0.56) |
| Change in height, cm‡ | 0.10 (−0.21 to 0.40) | 0.02 (−0.54 to 0.58) | 0.03 (−0.42 to 0.47) | 0.06 (−0.39 to 0.51) | 0.29 (−0.13 to 0.72) | 0.38 (−0.17 to 0.93) |
| WHZ§ | 0.29 (0.10–0.47) | 0.28 (0.10–0.45) | 0.03 (−0.20 to 0.27) | −0.09 (−0.34 to 0.16) | −0.07 (−0.25 to 0.11) | −0.06 (−0.31 to 0.19) |
| HAZ‖ | 0.02 (−0.06 to 0.11) | 0.02 (−0.15 to 0.18) | −0.03 (−0.17 to 0.11) | 0.003 (−0.13 to 0.14) | 0.08 (−0.03 to 0.20) | 0.14 (−0.06 to 0.33) |
| WAZ¶ | 0.23 (0.11–0.35) | 0.21 (0.10–0.31) | 0.04 (−0.11 to 0.18) | −0.03 (−0.15 to 0.09) | −0.01 (−0.12 to 0.11) | 0.03 (−0.14 to 0.20) |
| MUAC# | 0.12 (−0.18 to 0.43) | 0.10 (−0.16 to 0.35) | −0.19 (−0.47 to 0.08) | −0.27 (−0.55 to 0.01) | 0.19 (−0.13 to 0.51) | 0.12 (−0.22 to 0.45) |
HAZ = height-for-age Z score; MUAC = mid-upper arm circumference; WAZ = weight-for-age Z score; WHZ = weight-for-height Z score. Bold indicates statistically significant difference (P <0.05).
P value for joint test of significance in models comparing to placebo-treated household: P = 0.002.
P value for joint test of significance in models comparing to placebo-treated household: P = 0.001.
P value for joint test of significance in models comparing to placebo-treated household: P = 0.57.
P value for joint test of significance in models comparing to placebo-treated household: P = 0.002.
P value for joint test of significance in models comparing to placebo-treated household: P = 0.46.
P value for joint test of significance in models comparing to placebo-treated household: P = 0.0005.
P value for joint test of significance in models comparing to placebo-treated household: P = 0.03.